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    Jun 01 1996 · ω-Phosphono-substituted α-amino acids have long been known to be antagonists at the N-methyl-D-aspartate (NMDA) receptor. d-2-Amino-5-phosphonopentanoic (d-AP5) and d-2-amino-7-phosphonoheptanoic (d-AP7) acids are the "prototype" compounds of this kind sertion of a biphenyl-moiety in the middle of the AP7 chain results in increased affinity and reverses the enantioselectivity

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  • CPP a new potent and selective NMDA antagonist

    Sep 10 1986 · Properties of a new potent antagonist acting selectively at N-methyl-d-aspartate (NMDA) type excitatory amino acid receptors are described.This compound 3-((±)-2-car☐ypiperazin-4-yl)propyl-1-phosphonic acid (CPP) is more potent than all previously reported NMDA antagonists in depressing mammalian spinal neuronal responses ( and immature rat) in its affinity for 3 H d-AP5 (a

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